• Provide Clinical Science leadership for an assigned therapeutic area; partner with Medical Director/MST Lead to co-develop program strategy, evidence generation plans, and study concepts aligned to portfolio priorities. • Serve as Clinical Science lead on the MST and represent US Medical Affairs in key cross-functional forums and workstreams. • Lead scientific review, prioritization, and oversight of Investigator Initiated Trials (IITs) in partnership with Medical Affairs and governance stakeholders. • Lead and support external research collaborations (e.g., academic partnerships, consortium-based studies) from concept through execution, ensuring scientific quality and operational rigor. • Ensure consistent clinical science standards, governance, and best practices across IITs and external collaborations. • Drive Medical Office clinical trial acceleration across USMA to reduce cycle times and improve study start-up and execution. • Coordinate trial acceleration activities across Clinical Sciences, Medical Affairs, and cross-functional partners; establish clear milestones, owners, and accountability. • Identify, prioritize, and execute acceleration initiatives; translate strategic objectives into measurable operational impact (timelines, throughput, quality). • Act as an integrator across enabling functions (e.g., medical leadership, field medical, governance, contracts) to implement scalable acceleration ways of working. • Lead evidence generation acceleration initiatives (e.g., portfolio control tower approach, acceleration playbooks, external collaboration strategy). • Track, communicate, and continuously improve outcomes using data-driven insights, dashboards, and performance metrics. • Provide scientific and operational oversight for assigned studies/programs, including feasibility input and contributions to protocols and key study documents. • Oversee vendor, budget, and resource planning as applicable; ensure accurate forecasting and delivery against commitments. • Lead, coach, and develop a team of trial leads and/or matrixed resources; support hiring, retention, and capability building. • Ensure compliance with SOPs, GCP, and ethical requirements; contribute to continuous improvement of processes and working practices.