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Role Description

We’re looking for a knowledgeable and detail-oriented Manager or Senior Manager of Clinical Supply Chain to ensure our clinical trials are always ready to run - without delay, disruption, or waste. You'll be responsible for the end-to-end planning, execution, and oversight of clinical supply activities for assigned clinical programs and studies. You'll manage across the full study lifecycle, from protocol development and study startup through closeout, ensuring uninterrupted supply, regulatory compliance, and operational excellence.

This role calls for an experienced clinical supply pro who can manage complexity, proactively identify and mitigate risk, and partner across teams to support Praxis’s clinical development objectives.

Primary Responsibilities

• Supply strategy development for assigned clinical programs or studies, including forecasting and demand planning as well as packaging, labeling, and distribution oversight.
• Depot and site supply management.
• Returns, reconciliation, and destruction.
• Develop and maintain integrated supply plans aligned with protocol requirements and study timelines.
• Support study startup activities, including IRT design input, pharmacy manual development, and vendor onboarding.
• Monitor supply performance throughout study execution and proactively resolve issues related to supply shortages, excursions, and distribution challenges.
• Manage relationships with clinical supply vendors (e.g., depots, packaging/labeling vendors, couriers, IRT providers).
• Lead vendor forecasting discussions, review performance metrics, and manage issue resolution.
• Author, review, and approve clinical supply-related documents, including pharmacy manuals, supply plans, shipping documentation, vendor specifications, and work orders.
• Ensure all activities are conducted in compliance with GxP requirements, internal SOPs, and applicable regulations.
• Support inspection readiness activities and participate in audits and inspections as needed.
• Identify clinical supply risks and implement mitigation strategies to protect study timelines and patient safety.
• Support quality events, deviations, CAPAs, and change management activities.

Qualifications

• Bachelor’s degree in a scientific, clinical, or supply chain–related discipline (or equivalent experience) with a minimum of 5 to 8 years of experience in Clinical Supply management in a pharmaceutical or biotechnology environment – small or mid-sized biotech environment preferred.
• Experience supporting Phase 2 and/or Phase 3 clinical trials strongly preferred.
• Preferred hands-on experience with DTP/DFP models, IRT systems, and global clinical supply distribution.
• Demonstrated experience managing end-to-end clinical supply activities for clinical trials.
• Proven ability to independently manage multiple studies simultaneously.
• Strong working knowledge of GxP requirements and clinical trial operations.
• Preferred experience supporting audits and regulatory inspections.
• Strong organizational and project management skills.
• Proactive problem-solving and risk-based decision-making.
• Ability to operate independently with minimal supervision.
• Effective cross-functional communication and stakeholder management.
• Comfort operating in a fast-paced, evolving environment.

Requirements

• The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement.
• You'll need comfort with screen work, basic hand coordination, and focus.
• Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

Benefits

• 99% of the premium paid for medical, dental, and vision plans.
• Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage.
• Dollar-for-dollar match up to 6% on eligible 401(k) contributions.
• Long-term stock incentives and ESPP.
• Discretionary quarterly bonus.
• Extremely flexible wellness benefit.
• Generous PTO, paid holidays, and company-wide shutdowns.
• Join a phenomenal crew of colleagues who are smart, engaged, and inspiring.

Company Description

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis, we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high-impact medicines for patients and families affected by and living with complex brain disorders. Our core values of Trust, Ownership, Curiosity, and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.