Adaptive Biotechnologies Corp.
Every immune system has a story to tell; the key is knowing how to listen.
Principal Machine Learning Scientist
Machine Learning EngineerMachine Learning EngineerFull TimeRemoteLeadTeam 501-1,000Since 2009H1B No SponsorCompany SiteLinkedIn
Location
United States
Posted
3 days ago
Salary
$183.4K - $275K / year
Seniority
Lead
Job Description
• Design, implement, and train novel deep learning architectures for TCR–pMHC specificity prediction.
• Extend and adapt advances in protein language models, structure prediction, generative modeling, and representation learning to the immune receptor setting.
• Leverage and influence scalable training infrastructure to support large-scale model development and experimentation.
• Lead rigorous benchmarking and evaluation strategies to ensure models are scientifically sound and practically superior.
• Translate biological principles of T cell recognition into principled modeling decisions.
• Influence large-scale experimental data generation to maximize modeling leverage and long-term performance gains.
• Evaluate emerging ML advances and determine when and how to incorporate them into Adaptive’s modeling roadmap.
• Shape the long-term technical direction of machine learning in immune receptor prediction across the organization.
• Partner with computational biology, immunology, translational, and engineering teams to ensure models are capable, scalable, reproducible, and aligned with therapeutic and diagnostic goals.
• Clearly communicate complex modeling insights to scientific leadership, executives, and external partners.
• Contribute to intellectual property development and high-impact publications.
Job Requirements
- PhD in a quantitative discipline (e.g. Machine Learning, Computational Biology, Computer Science, etc.) + 12 years progressive experience in machine learning, applied statistics or related field in a life sciences or biotech environment or similar combination of education and experience; an advanced degree preferred.
- Masters + 15 years of progressive experience, or
- Bachelors + 17 years of progressive experience
- Progressive experience in the conception, development and deployment of deep learning methods including substantial hands-on model development
- Demonstrated track record of innovating and implementing novel machine learning solutions to biological problems, as demonstrated by publications, conference papers, patents, or delivered products.
- Deep expertise in python and modern ML tooling (PyTorch preferred)
- Experience with version control and ML experiment tracking
- Proven ability to independently define, scope, and execute complex technical research problems.
- Excellent written and verbal communication skills, with ability to present highly technical material to diverse audiences.
- Exceptional depth in deep learning architecture design and implementation.
- Comfortable operating at the frontier of both ML and immunology.
- Strategic thinker capable of influencing technical direction across teams.
- Driven by impact: motivated to see models transition from research to clinical and commercial application.
Benefits
- equity grant
- bonus eligible
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