Adaptive Biotechnologies Corp. logo
Adaptive Biotechnologies Corp.

Every immune system has a story to tell; the key is knowing how to listen.

Principal Machine Learning Scientist

Machine Learning EngineerMachine Learning EngineerFull TimeRemoteLeadTeam 501-1,000Since 2009H1B No SponsorCompany SiteLinkedIn

Location

United States

Posted

3 days ago

Salary

$183.4K - $275K / year

Seniority

Lead

Postgraduate Degree12 yrs expExperience acceptedEnglishPythonPyTorch

Job Description

• Design, implement, and train novel deep learning architectures for TCR–pMHC specificity prediction. • Extend and adapt advances in protein language models, structure prediction, generative modeling, and representation learning to the immune receptor setting. • Leverage and influence scalable training infrastructure to support large-scale model development and experimentation. • Lead rigorous benchmarking and evaluation strategies to ensure models are scientifically sound and practically superior. • Translate biological principles of T cell recognition into principled modeling decisions. • Influence large-scale experimental data generation to maximize modeling leverage and long-term performance gains. • Evaluate emerging ML advances and determine when and how to incorporate them into Adaptive’s modeling roadmap. • Shape the long-term technical direction of machine learning in immune receptor prediction across the organization. • Partner with computational biology, immunology, translational, and engineering teams to ensure models are capable, scalable, reproducible, and aligned with therapeutic and diagnostic goals. • Clearly communicate complex modeling insights to scientific leadership, executives, and external partners. • Contribute to intellectual property development and high-impact publications.

Job Requirements

  • PhD in a quantitative discipline (e.g. Machine Learning, Computational Biology, Computer Science, etc.) + 12 years progressive experience in machine learning, applied statistics or related field in a life sciences or biotech environment or similar combination of education and experience; an advanced degree preferred.
  • Masters + 15 years of progressive experience, or
  • Bachelors + 17 years of progressive experience
  • Progressive experience in the conception, development and deployment of deep learning methods including substantial hands-on model development
  • Demonstrated track record of innovating and implementing novel machine learning solutions to biological problems, as demonstrated by publications, conference papers, patents, or delivered products.
  • Deep expertise in python and modern ML tooling (PyTorch preferred)
  • Experience with version control and ML experiment tracking
  • Proven ability to independently define, scope, and execute complex technical research problems.
  • Excellent written and verbal communication skills, with ability to present highly technical material to diverse audiences.
  • Exceptional depth in deep learning architecture design and implementation.
  • Comfortable operating at the frontier of both ML and immunology.
  • Strategic thinker capable of influencing technical direction across teams.
  • Driven by impact: motivated to see models transition from research to clinical and commercial application.

Benefits

  • equity grant
  • bonus eligible

Related Job Pages

More Machine Learning Engineer Jobs

Full TimeRemoteTeam 201-500

The Machine Learning Engineer will be responsible for designing, training, and deploying predictive models specifically for adversarial systems. Additionally, they must build and maintain high-performance ML infrastructure that can scale from research prototypes to production environments.

United States
$200K - $300K / year
Full TimeRemoteTeam 10,001+Since 1978H1B No Sponsor

Senior Machine Learning Engineer designing AI-powered applications for Home Depot

United States
$100K - $180K / year
Full TimeRemoteTeam 10,001+Since 1978H1B No Sponsor

Machine Learning Engineer II designing AI applications for Home Depot

United States
$90K - $170K / year