• Leads a large clinical study or a series of related studies with minimal guidance. • Represents Data Management at study management team meetings. • Provides mentoring and training to lower-level Data Management staff assigned to his/her studies Manage and monitor the progress of data management activities with CROs or other vendors on assigned studies; build effective relationships with CRO / vendor counterparts. • Reviews protocols for appropriate data capture including electronic Case Report Form (eCRF) design. • Performs a thoroughly detailed review of eCRF data requirements and create one if need be. • Interacts with CRAs, programmers, study operations lead and statisticians in designing eCRFs and creating the annotated eCRF and CRF completion guidelines. • Leads the development of data edit check specifications and data listings. • Coordinates the design and testing of Electronic Data Capture (EDC) systems according to company processes. • Resolves EDC system issues with team members. • Develops or lead the development of the Data Management Plan for a clinical study. • Reviews and provides feedback to the clinical team on other study documents Statistical analysis plans and vendor specifications. • Provides training on the EDC system and/or eCRF Completion Guidelines at Investigator Meetings and to internal and external study team members as needed. • Performs reconciliation of data from external data sources against the clinical database. • Performs Serious Adverse Event reconciliation activities according to SOPs and guidelines. • Leads database upgrades/migrations including performing User Acceptance Testing. • Performs database lock and freeze activities per company SOPs. • Adheres to Iovance Biotherapeutics’ core values, policies, procedures, and business ethics. • Performs miscellaneous duties as assigned.