Amgen

#WeareBiotech

Principal Scientist – Research Computational Biology

Research ScientistResearch ScientistFull TimeRemoteTeam 10,001+Since 1980H1B SponsorCompany SiteLinkedIn

Location

United States

Posted

35 days ago

Salary

$168.5K - $203.0K / year

Postgraduate Degree2 yrs expEnglishCloudLinuxPythonUnix

Job Description

• The ARIA Computational Biology team is seeking a talented and creative computational biologist to further our mission of serving patients by advancing and replenishing the Amgen therapeutic pipeline • In this role you will apply your expertise in data science and disease biology to accelerate the identification, prioritization, and validation of transformative therapeutic targets in a dynamic cross-functional research environment • Your scientific and technical leadership will help shape computational biology strategy across multiple discovery programs, influencing target selection, biomarker strategy, and translational hypotheses • Driving extraction of biological insight from complex multi-modal omics and screening data to characterize disease endotypes and mechanisms, identify novel targets and biomarkers, and test therapeutic hypotheses • Developing and leveraging methods/platforms to discover, prioritize, and validate targets across diverse diseases and therapeutic modalities • Innovative research in close partnership with Amgen therapeutic area scientists, spanning both internal pipeline programs and external partnerships • Shaping roadmap priorities with our data science and information systems teams to incorporate tools and analyses developed within ARIA Computational Biology into integrated R&D platforms

Job Requirements

  • Doctorate in computational biology, bioinformatics, data science, or a related discipline [and relevant post-doc where applicable] and 2 years of computational biology experience
  • Or Master’s degree and 5 years of computational biology experience
  • Or Bachelor’s degree and 7 years of computational biology experience
  • Strong research background in cardiometabolic disease and/or immunology
  • Proven track record of driving programs or platforms that have materially impacted discovery or early development decisions
  • Experience mentoring scientists and setting standards for computational best practices within a team
  • Strong programming skills (Python, R, Linux/Unix)
  • Familiarity with cloud computing environments, HPC, and collaborative coding practices (e.g., Git)
  • Track record of designing and implementing creative and holistic computational strategies to address challenging research questions
  • Demonstrated expertise in the analysis and interpretation of single cell omics data
  • Excellent presentation and communication skills to convey complex findings to diverse audiences
  • Experience leveraging and fine-tuning transcriptional foundation models, LLMs, and biomedical knowledge graphs to further research goals
  • Familiarity with public data resources (e.g. DepMap, Human Cell Atlas, TCGA, GTEx, and Tahoe-100M)
  • Experience developing and deploying tools and pipelines to endpoints such as interactive portals (e.g. RShiny, Streamlit), workflow management systems (e.g Nextflow), and agentic frameworks

Benefits

  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions
  • group medical, dental and vision coverage
  • life and disability insurance
  • flexible spending accounts
  • A discretionary annual bonus program
  • stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models, including remote and hybrid work arrangements, where possible

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