Centessa Pharmaceuticals, LLC

This role serves as a senior legal partner, providing strategic and day-to-day legal support across corporate, commercial, and operational matters, including leading the drafting and negotiation of complex commercial agreements like global clinical trial and CRO/CDMO engagements. The director will also advise on legal risks for global clinical development, support corporate governance, assist with SEC compliance, and manage external counsel worldwide.

This role is accountable for operational leadership across IT service management, cloud platform operations, cybersecurity operations, and core governance controls, leading service delivery in a hybrid/outsourced model by setting standards and governing vendors.

The (Senior) Manager, Statistical Programming will support statistical programming activities across therapeutic areas, ensuring high-quality data analysis and compliance with regulatory standards. This role involves collaborating with cross-functional teams to execute programming deliverables and support clinical development planning.

Centessa is currently seeking an (Associate) Director, Clinical Supply Chain. The successful candidate will develop and implement strategies to deliver Clinical Trial Materials (CTM) in support of several clinical programs. Reporting to the Senior Director, Clinical Supply Chain,...

The Director partners with the Global Team Leader to manage cross-functional matrix teams, developing and maintaining integrated program plans, timelines, and risk management frameworks as the company's 'Single Source of Truth'. This role drives operational rigor by facilitating core team meetings, managing dashboards, issues, risks, coordinating budgets, and supporting governance and regulatory submission activities.

The Director of Medical Affairs Operations will establish and lead the operational function within Medical Affairs, ensuring strategies are executed effectively, compliantly, and with operational excellence. Key duties include overseeing strategic planning, budget management, medical governance, systems implementation, and cross-functional coordination.

The Associate Director, Toxicology will oversee toxicology and safety pharmacology studies conducted at CROs, ensuring high-quality monitoring and timely execution to support small molecule orexin receptor agonist development. This individual will manage outsourced studies, liaise with CRO partners, ensure regulatory compliance, and contribute to IND/CTA and NDA submission packages.