#WeareBiotech
Senior Principal Scientist – Antibody-siRNA Bioanalytical, Biodistribution Strategy Lead
Location
United States
Posted
4 days ago
Salary
$184.0K - $204.8K / year
Job Description
Job Requirements
- Doctorate degree [and relevant post-doc where applicable] in pharmacology, biochemistry or a related-scientific discipline and 3 years of industry experience
- Or Master’s degree in pharmacology, biochemistry or a related-scientific discipline and 6 years of industry experience
- Or Bachelor’s degree in pharmacology, biochemistry or a related-scientific discipline and 8 years of industry experience
- Extensive knowledge of antibody-siRNA conjugate ADME and pharmacokinetics
- Experience with respect to other siRNA modalities, antibody-drug conjugates, peptide conjugates, biologics and/or small molecules
- Experience investigating biodistribution and metabolism of siRNA conjugated to a tissue-targeting ligand
- Expertise in antibody-siRNA bioanalytical approaches and considerations
- Extensive experience with ligand binding assays (specifically immunoassay and hybridization assays) and LC/MS bioanalytical platforms
- Experience with respect to RT-qPCR and/or RT-ddPCR
- Exceptional written and verbal communication skills
- Experience with regulatory filings for antibody-siRNA conjugates and/or other targeted delivery siRNA therapeutics.
Benefits
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions
- group medical, dental and vision coverage
- life and disability insurance
- flexible spending accounts
- A discretionary annual bonus program
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible.
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