Amgen

#WeareBiotech

Senior Principal AI/ML Scientist, Computational Imaging

Artificial IntelligenceArtificial IntelligenceFull TimeRemoteTeam 10,001+Since 1980H1B SponsorCompany SiteLinkedIn

Location

United States

Posted

54 days ago

Salary

Not specified / year

Postgraduate Degree3 yrs expEnglishAWSAzureCloudGoogle Cloud PlatformPythonPy TorchTensorflow

Job Description

• Lead the design, development, training, and validation of AI/ML models for digital pathology and/or radiology applications • Define technical direction for custom AI/ML model development, including architecture selection, training paradigms, validation strategies, and performance benchmarks • Develop custom deep learning architectures and workflows for segmentation, classification, representation learning, and prediction tasks • Leverage and adapt foundation models (e.g., vision transformers, multimodal and self-supervised models), including fine-tuning and domain adaptation using proprietary datasets • Extract insights from large-scale imaging datasets, including whole-slide images and radiology modalities (CT, MRI, PET) • Apply advanced computer vision and machine learning methods, including CNNs, U-Net variants, Vision Transformers, diffusion-based or representation-learning models • Define appropriate evaluation strategies and ensure analytical rigor, reproducibility, and scientific credibility • Integrate imaging data with clinical, molecular, or spatial-omics data where relevant • Balance innovation with practicality, ensuring solutions are scalable, interpretable, and fit-for-purpose • Work closely with pathologists, radiologists, clinicians, and translational scientists to translate scientific questions into computational imaging solutions • Clearly communicate modeling approaches, assumptions, results, and limitations to technical and non-technical stakeholders • Contribute to shaping project-level research questions and study designs involving imaging data • Support external collaborations through technical input and scientific exchange as needed • Contribute to the organization’s scientific visibility through publications, presentations, and internal knowledge sharing • Provide informal mentorship and technical guidance to junior scientists and collaborators • Stay current with advances in AI, computer vision, and medical imaging to continuously elevate technical approaches.

Job Requirements

  • Doctorate degree in Computer Science, Artificial Intelligence, Machine Learning, Electrical Engineering, Computational Biology, or a related quantitative field and 3 years of related experience
  • Or Master’s degree in Computer Science, Artificial Intelligence, Machine Learning, Electrical Engineering, Computational Biology, or a related quantitative field and 6 years of related industry experience
  • Or Bachelor’s degree in Computer Science, Artificial Intelligence, Machine Learning, Electrical Engineering, Computational Biology, or a related quantitative field and 8 years of related industry experience
  • Demonstrated deep technical expertise in developing custom AI/ML models for medical imaging
  • Strong experience in digital pathology and/or radiology, including whole-slide images and/or modalities such as CT, MRI, or PET
  • Expertise in foundation model usage, including pre-training, fine-tuning, and domain adaptation for imaging-based tasks
  • Advanced knowledge of modern computer vision and ML techniques, including: CNNs, U-Net–based architectures, Vision Transformers, Self-supervised, weakly supervised, and few-shot learning, Multimodal and representation learning approaches
  • Proficiency in Python and deep learning frameworks such as PyTorch and/or TensorFlow.
  • Demonstrated ability to communicate complex technical concepts clearly and influence scientific decision-making
  • Strong record of scientific contributions (e.g., publications, patents, deployed models, or platform capabilities)
  • Demonstrated evidence of setting and implementing technical or scientific strategies for complex AI/ML or computational imaging initiatives, including defining problem statements, selecting modeling approaches, and driving execution to measurable scientific or translational outcomes
  • Strong publication record in AI/ML, with particular emphasis on applications to drug development, biomarker discovery, patient stratification, or translational research; contributions to high-impact journals or top-tier AI/medical imaging conferences strongly preferred
  • Experience working with integrated imaging, clinical, and molecular datasets
  • Familiarity with MLOps, scalable training, and model lifecycle management
  • Experience with cloud or HPC environments (e.g., AWS, Azure, GCP, SLURM), containerization, and distributed training
  • Prior experience leading significant components of cross-functional or external collaboration.

Benefits

  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions
  • group medical, dental and vision coverage
  • life and disability insurance
  • flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible.

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