Spyre Therapeutics

Engineering for new heights in the treatment of inflammatory bowel disease

Executive Medical Director, Clinical Development

Medical DirectorMedical DirectorFull TimeRemoteTeam 11-50H1B No SponsorCompany SiteLinkedIn

Location

United States

Posted

139 days ago

Salary

$365K - $396K / year

Professional Certificate6 yrs expEnglishGoogle Cloud Platform

Job Description

• Provide strategic leadership and medical expertise for the clinical development of our cutting-edge antibody portfolio in IBD. • Design, plan, and oversee the execution of clinical studies, with a focus on proof-of-concept and later-stage development. • Partner with teams across Biostatistics, Regulatory Affairs, Development Operations, Translational Science, and other key functions to ensure cohesive and efficient program execution. • Contribute medical and scientific content for regulatory documents including INDs, Investigator Brochures, Clinical Study Reports, and regulatory submissions and responses. • Ensure participant safety through proactive safety monitoring, data review, and clinical judgment in response to emerging data. • Serve as a primary medical representative for assigned programs, interfacing with investigators, academic experts, and key opinion leaders (KOLs). • Provide medical leadership within clinical teams and mentor as the organization grows. • Support strategic portfolio decisions and organizational initiatives as needed.

Job Requirements

  • Education: MD or equivalent medical degree is required, board certification in a relevant specialty preferred.
  • Minimum of 6+ years clinical development experience within the pharmaceutical or biotech industry, with significant experience in immunology and/or inflammation indications.
  • Experience with antibody therapeutics preferred.
  • Demonstrated success in designing, executing, and interpreting IBD clinical trials.
  • Prior experience with regulatory submissions and interactions (e.g., INDs, CTAs, NDAs, BLAs).
  • Deep understanding of GCP, clinical trial design, biostatistics, and global regulatory expectations.
  • Excellent communication and presentation skills with the ability to collaborate effectively across scientific, operational, and executive teams.
  • Strategic mindset combined with strong operational execution capabilities.
  • Proven ability to thrive in a fast-paced, entrepreneurial environment.

Benefits

  • Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.
  • Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
  • Unlimited PTO
  • Two, one-week company-wide shutdowns each year
  • Commitment to provide professional development opportunities.
  • Remote working environment with frequent in-person meetings to address complex problems and build relationships.

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