• Support Crinetics’ translational and early clinical programs by applying mechanistic and quantitative modeling to guide decision-making • Conduct PBPK and/or QSP modeling directly and/or work with external partners to integrate preclinical, in vitro, biomarker, and early clinical data into predictions • Help identify quantitative needs at key development milestones and ensure modeling results are translated into clear, actionable insights • Contribute to scientific review and provide input on population PK, PK/PD, and exposure–response analyses performed internally or through CRO partners • Inform efficient study designs using mechanistic and empirical modeling to guide dose selection, sampling, and biomarker strategy • Draft, develop and review program‑level quantitative analysis plans • Communicate modeling results clearly to project teams, supporting decision-making and governance discussions • Contribute modeling content to regulatory submissions (e.g., INDs, NDAs, IBs) with increasing independence • Support departmental objectives, mentor junior staff as appropriate