The Senior Director, US Medical Affairs, will be responsible for developing and executing the US Medical Affairs (USMA) strategy and tactical plans with a focus on launch readiness and life cycle management for an individual asset in gastrointestinal (GI). Develops and executes the USMA strategy and medical objectives including activities related to scientific engagement and communication, evidence generation, internal education, and patient advocacy. Develops and executes a Health Care Professional (HCP) engagement strategy to gather insights to inform the medical strategy. Acts as the US medical representative on cross-functional teams. Serves as a therapeutic area content expert. Participates in the Global Medical Affairs Team (GMAT) and US Medical Affairs Team (USMAT) to execute medical strategies, contribute to the operations and oversight of medical activities, and work cross-functionally to support associated pre-launch activities. Supports the execution of routine gap assessments leading to the development/refinement of a publication strategy, an evidence generation plan, and tactical plan as part of the overall USMA plan. Provides medical leadership in scientific engagement activities with key external stakeholders through organizing and leading advisory boards, studies investigator interactions, congress activities, and peer-to-peer discussions with the goal of communicating scientific insights to internal teams to drive strategy. Communicates clinical and scientific data to KOLs and other healthcare professionals through presentations, educational programs, and scientific discussions. Represents various medical affairs functions in cross-functional strategy team meetings including Clinical and Safety sub-teams, Global Brand Team, Global Product Team, Patient Advocacy, Market Access, and other cross-functional strategic discussions. Works closely with the Clinical and US MSL teams to provide enrollment, scientific, and engagement support to ensure clinical trials meet study timelines. Partners with RWE strategy and Biomarker/CDx teams on related integrated evidence generation strategies and activities as part of the USMA Plan. Works with the Patient Advocacy and Grants teams to incorporate the patient voice and define external medical education strategies for independent grants, respectively. Provides medical support for medical congresses and collaborates across US and Global functions to develop, review, and align on key scientific communication points and medical information response documents within legal and compliance guidelines. Supports the review and approval of abstracts, manuscripts, corporate communications, and other data disclosure documents as well as internal stakeholder medical education activities related to the compound data and related competitor data. Collaborates with stakeholders across the organization, including, but not limited to, Clinical Development and Operations, Commercial Operations, Program Management, Business Development, Regulatory, Safety, and Compliance teams.