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Role Description

Parabilis Medicines is seeking a Senior Director, Clinical Sciences to provide scientific and strategic leadership across our clinical development programs. This role is central to translating discovery and preclinical innovation into high-quality, data-driven clinical development strategies that advance our pipeline efficiently and responsibly.

As Senior Director, Clinical Sciences, you will:

• Lead and own clinical science strategy for one or more clinical programs across development stages
• Drive scientific input into protocol design, endpoint selection, and clinical development plans
• Serve as a core contributor to regulatory interactions, governance decisions, and program reviews
• Influence portfolio strategy through integrated clinical and translational insights
• Partner closely with Clinical Operations to ensure scientifically sound and feasible trial execution
• Interpret and contextualize clinical, biomarker, and safety data to inform decision-making
• Contribute to regulatory documents (INDs, IBs, briefing packages) and regulatory interactions
• Support investigator meetings, advisory boards, and external scientific communications
• Ensure consistency of scientific messaging across internal and external stakeholders
• Mentor and guide junior clinical scientists as the organization grows
• Leverage AI-enabled tools to enhance clinical insights, literature analysis, data interpretation, and operational efficiency

Qualifications

• PhD, PharmD, or equivalent advanced degree in life sciences, medicine, or a related field
• 10+ years of experience in clinical development or clinical sciences within biotech or pharmaceutical settings
• Direct experience supporting or leading clinical trials (Phase 1–3 preferred)
• Proven track record of contributing to successful clinical programs and regulatory milestones
• Deep understanding of clinical trial design, endpoints, and regulatory requirements
• Experience working with clinical data systems, trial databases, and scientific literature platforms
• Familiarity with biomarker and translational data integration
• Strong scientific writing and data presentation skills
• Experience in rare disease, oncology, immunology, or other complex therapeutic areas (as applicable to Parabilis’ pipeline)
• Prior leadership or matrix-management experience
• Experience interacting with regulatory agencies and external experts
• Strong strategic thinking combined with hands-on execution
• Comfort operating in a fast-paced, evolving biotech environment
• Demonstrated use of AI tools in your current role and responsibilities is required. Advanced or innovated use of AI is a strong plus.

Benefits

• Base salary range: $265,000–$305,000 per year, depending on experience, qualifications, and internal practices
• Annual target bonus
• Equity
• Comprehensive suite of competitive benefits designed to support employees’ overall well-being

Core Values

• Growth-Minded: We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent: We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused: We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In: We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.