• Provide Safety Science leadership for clinical development programs and program teams and integrate safety science strategy with clinical development. • Represent GPV in communication with health and regulatory authorities. • Represent GPV at independent Data Safety Monitoring Committee meetings. • Provide medical oversight of the GPV function including medical review of all cases. • Provide medical input for maintaining REMS, RMP safety monitoring commitments. • In collaboration with other members of GPV, create and maintain a signal detection process for Erasca’s products with a clearly defined signal detection strategy for each asset. • In collaboration with other members of GPV, ensure robust processes are implemented to meet REMS/RMP commitments. • Overall responsibility for development and implementation of QPV, in collaboration with Quality and GPV Systems. • Provide periodic benefit-risk assessment reports for internal use. • Contribute to the preparation of, review, and approve aggregate safety reports required by health authorities. • Serve as SME author, reviewer, and approver for drug-safety related regulatory reports and clinical study documents (including clinical study protocols, Informed Consent Forms, Investigator Brochures, Integrated Summary of Safety (ISS), Integrated Summary of Efficacy (ISE), product package labeling, Company Core Safety Information, etc). • Work with external partners to jointly manage cases, safety reporting, and signal detection across global development for molecule candidates. • Manage implementation and/or operation of data analytics and data reporting tools to support drug safety compliance and analysis. • Build and lead highly functioning GPV team including Safety Operations and Safety Science, utilizing internal and external resources. • Develop operating plans and budgets and allocate resources to ensure budgets, schedules, and performance requirements are met. • Assess process, systems, and staffing needs to scale for multiple late-stage trials, including oversight of CROs and vendors. • Develop and maintain relationships across Erasca, particularly in Clinical Development, Clinical Operations, Biometrics, and Regulatory Affairs. • Perform all duties in keeping with the Company’s core values, policies, and all applicable regulations.