• Own the development and execution of integrated U.S. payer strategies across the Ionis commercial portfolio. • Establish long-range access vision, coverage objectives, and reimbursement strategies aligned with brand and corporate priorities. • Shape and implement enterprise-level access frameworks that can scale across current and future launches. • Identify, quantify, and proactively mitigate access risks and reimbursement barriers. • Provide forward-looking analysis of payer landscape shifts, policy changes, and competitive access dynamics. • Lead U.S. access readiness strategy from pre-launch planning through lifecycle optimization. • Oversee development of payer-facing and field access materials. • Ensure alignment of clinical and economic evidence generation with payer requirements in partnership with HEOR and Medical Affairs. • Influence economic modeling, value frameworks, and budget impact strategies to support coverage negotiations. • Oversee pull-through strategies to accelerate coverage adoption and minimize patient access friction. • Lead and develop a high-performing U.S. Value & Access organization and drive team execution to achieve measurable access outcomes. • Establish clear strategic priorities and ensure alignment of resources against enterprise objectives. • Build scalable capabilities to support portfolio expansion and future product launches. • Foster a culture of collaboration, accountability, and continuous improvement. • Partner closely with Brand, Medical Affairs, HEOR, Regulatory, Government Affairs, Pricing, Field Access, and Sales leadership to ensure cohesive execution. • Integrate payer insights into brand planning, evidence strategies, and lifecycle investment decisions. • Provide executive-level recommendations to senior leadership on reimbursement strategy and payer engagement.